Emanuele Luigi Carniel
Department of Industrial Engineering, University of Padova
Via Venezia 1, 35131 Padova, Italy
tel +39 049 8276876
e-mail emanueleluigi.carniel@unipd.it
Research Activity
Within the multidisciplinary framework of the Centre for Mechanics of Biological Materials, Emanuele Luigi Carniel and his group conduct research on the mechanical functionality of biological tissues and structures. The activities involve researchers from many different disciplines, including engineering, materials science, computer science, mathematics, anatomy, physiology, medicine and surgery.
The aim of the research is to optimise biomedical devices and techniques, focusing on mechanical and mechanobiological factors. Activities are defined taking into account the real needs of clinical and surgical practice, as well as collaboration with industrial partners.
Today, research focuses on in silico medicine, with particular emphasis on the mechanical functionality of the lower urinary tract, the mechano-physiology of gastrointestinal structures and the mechanics of joints. Novel techniques and devices are rationally designed and validated through the synergistic integration of in vitro experiments on human and animal tissues and structures, in vivo experiments on animal models, constitutive characterisation of biological tissues and biomaterials, in silico modelling and clinical trials. Experiments are designed to geometrically and mechanically identify analytical and computational models of the biological tissues and the anatomical districts. The models are then used to assess the functional response under a variety of conditions. In line with the 3R approach, the method maximises reproducibility while reducing the need for biological samples.
Five most representative publications
- Mascolini, M.V., Fontanella, C.G., Berardo, A., Carniel, E.L., Influence of transurethral catheters on urine pressure-flow relationships in males: A computational fluid-dynamics study
(2023) Computer Methods and Programs in Biomedicine, 238, art. no. 107594.
DOI: 10.1016/j.cmpb.2023.107594 - Toniolo, I., Berardo, A., Gagner, M., Foletto, M., Carniel, E.L., Unveiling the effects of key factors in enhancing gastroesophageal reflux: A fluid-structure analysis before and after laparoscopic sleeve gastrectomy (2023) Computer Methods and Programs in Biomedicine, 231, art. no. 107409.
DOI: 10.1016/j.cmpb.2023.107409 - Fontanella, C.G., Belluzzi, E., Pozzuoli, A., Favero, M., Ruggieri, P., Macchi, V., Carniel, E.L., Mechanical behavior of infrapatellar fat pad of patients affected by osteoarthritis (2022) Journal of Biomechanics, 131, art. no. 110931.
DOI: 10.1016/j.jbiomech.2021.110931 - Toniolo, I., Fontanella, C.G., Foletto, M., Carniel, E.L., Coupled experimental and computational approach to stomach biomechanics: Towards a validated characterization of gastric tissues mechanical properties (2022) Journal of the Mechanical Behavior of Biomedical Materials, 125, art. no. 104914.
DOI: 10.1016/j.jmbbm.2021.104914 - Carniel, E.L., Albanese, A., Fontanella, C.G., Pavan, P.G., Prevedello, L., Salmaso, C., Todros, S., Toniolo, I., Foletto, M., Biomechanics of stomach tissues and structure in patients with obesity (2020) Journal of the Mechanical Behavior of Biomedical Materials, 110, art. no. 103883.
DOI: 10.1016/j.jmbbm.2020.103883