Silvia Todros
Department of Industrial Engineering, University of Padova
Via Venezia 1, 35131 Padova, Italy
tel +39 049 8276878

Research Activity

Silvia Todros carries out research activities mainly aimed at the characterization of physicochemical, morphological and mechanical properties of biomaterials, biomedical devices and biological tissues, with experimental techniques and computational modelling.

Her main research topics are the following;

  • mechanics of biomaterials for tissue engineering and regenerative medicine:

experimental and computational analysis of the mechanical behavior of hydrogels for different applications in tissue engineering;
development of scaffold based on muscle extracellular matrix (ECM) for muscle tissue engineering: characterization of physicochemical, morphological and mechanical properties of ECM-based scaffolds; development of bioinks for 3D bioprinting; design and development of bioreactors for the mechanical stimulation of engineered tissues and scaffolds;
computational analysis of cardiomyocyte biomechanics for the evaluation of activation capability of cardiomyocyte layers on hydrogel scaffolds for regenerative medicine.

  • mechanics of polymeric biomaterials and biomedical devices:

analysis of synthetic surgical meshes for the repair of abdominal hernias and pelvic organ prolapses, through experimental characterization of the chemical-physical and mechanical properties of biomaterials and prosthetic meshes;
computational analysis of the biomechanics of the abdominal wall and the interaction between surgical meshes and biological tissues following repair, to provide support to the surgeons in selecting the most suitable prosthetic element.

  • mechanics of biological tissues:

experimental analysis of the mechanical behavior of human or animal tissue, by means of uniaxial and biaxial tensile tests, stress relaxation tests, confined and unconfined compression, friction tests;
investigation of the effects of decellularization treatment on the mechanical properties of biological tissues.

Five most representative publications

  • Todros, S., Spadoni, S. Barbon, S., Stocco, M. Confalonieri, E., Porzionato, A., Pavan, P.G., Compressive mechanical behavior of partially oxidized polyvinyl alcohol hydrogels for cartilage tissue repair (2022), Bioengineering, 9(12), 789, DOI: 10.3390/bioengineering9120789
  • Todros, S., Barbon, S., Stocco, E., Favaron, M., Macchi, V., De Caro, R., Porzionato, A., Pavan, P.G., Time-dependent mechanical behavior of partially oxidized polyvinyl alcohol hydrogels for tissue engineering (2022), Journal of Mechanical Behavior of Biomedical Material, 125, 104966. DOI: 10.1016/j.jmbbm.2021.104966
  • Boso, D., Carraro, E., Maghin, E., Todros, S., Giomo, M., Elvassore, N., De Coppi, P., Pavan, P.G., Piccoli, M., Porcine decellularized diaphragm hydrogel: a new option for skeletal muscle malformations (2021), Biomedicines, 9(7), 709. DOI:10.3390/biomedicines9070709
  • Todros, S., de Cesare, N., Concheri, G., Natali, A.N., Pavan, P.G., Numerical modelling of abdominal wall mechanics: the role of muscular contraction and intra-abdominal pressure (2020), Journal of the Mechanical Behavior of Biomedical Materials, 103, 103578. DOI: 10.1016/j.jmbbm.2019.103578
  • Todros, S., de Cesare, N., Pianigiani, S., Concheri, G., Savio, G., Natali, A.N., Pavan, P.G. 3D surface imaging of abdominal wall muscular contraction (2019) Computer Methods and Programs in Biomedicine, 175, pp. 103-109. DOI: 10.1016/j.cmpb.2019.04.013